Mitogen-activated protein kinase kinase



Mitogen-activated protein kinase kinase (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of MAPK and MAP3K which are activated by phosphorylation. MAP2K activates MAPK. The images on the left and right correspond to one representative MAP2K structure, i.e. the human MAP2K1 (3e8n).

3D Structures of Mitogen-activated protein kinase kinase
Update June 2011

MAP2K1
3mbl, 3e8n, 3dy7, 3eqb, 2p55 – hMAP2K1 kinase domain +MgADP+ligand - human

3eqc – hMAP2K1 kinase domain+ATP-Gs+Mg2P

3eqd - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P

3eqf - hMAP2K1 kinase domain (mutant)+inhibitor+Mg2P

3eqg, 3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd

3eqh - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor

3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd

3dv3 - hMAP2K1 residues 62-382+inhibitor

1s9j – hMAP2K1 +MgATP+ligand

1sko - hMAP2K1+P14

3cpt - hMAP2K1+P14 (mutant)

1vet, 1veu - MAP2K1+P14 - mouse

MAP2K2
1s9i – hMAP2K2 +MgATP+ligand

1jky - hMAP2K2 + Anthrax lethal factor

MAP2K3
2o2v – hMAP2K3+ hMAP3K5

MAP2K4
3aln - hMAP2K4 kinase domain +AMPPNP

MAP2K5
1p38 – hMAP2K5+hMAP2KK2

MAP2K6
3enm – hMAP2K6 (mutant)

3fme – hMAP2K6 kinase domain (mutant)

MAP2K7
2dyl – hMAP2K7 kinase domain (mutant)